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Statins increase the onset of diabetes at a rate of approximately 1 case per 1000 patients per year of treatment , but statins prevent about 5 cardiovascular events per 1000 patients.
New diabetes onset is greatest in those with pre-statin risk factors for diabetes.
Statin treatment and extremely low LDL-cholesterol levels from other cholesterol treatment do not affect cognitive function.
Statins do not reduce renal function and may actually protect the kidney, but this possibility requires further study.
Mild increases in ALT occur in patients on statins, but do not alone signify clinically significant disease.
Clinically important liver injury can occur with statins, but this is extremely rare and is likely a statin class effect.
Routinely monitoring of liver enzymes is not necessary or clinically justified.
Statins reduce the risk of first and subsequent ischemic strokes , but may produce a small increase in hemorrhagic stroke in individuals with prior stroke.
These messages should be useful in dispelling some of the myths about statin therapy and encouraging more patients to take these life-saving medications.
